Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches.

ABSTRACT: Neurotoxicology is the study of adverse effects on the structure or function of the developing or mature adult nervous system following exposure to chemical, biological, or physical agents. The development of more informative alternative methods to assess developmental (DNT) and adult (NT) neurotoxicity induced by xenobiotics is critically needed. The use of such alternative methods including in silico approaches that predict DNT or NT from chemical structure (e.g., statistical-based and expert rule-based systems) is ideally based on a comprehensive understanding of the relevant biological mechanisms. This paper discusses known mechanisms alongside the current state of the art in DNT/NT testing. In silico approaches available today that support the assessment of neurotoxicity

SUBMITTER: Crofton KM 

PROVIDER: S-EPMC9281386 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature