Construction and Validation of a m7G-Related Gene-Based Prognostic Model for Gastric Cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common malignant tumors of the digestive system. Chinese cases of GC account for about 40% of the global rate, with approximately 1.66 million people succumbing to the disease each year. Despite the progress made in the treatment of GC, most patients are diagnosed at an advanced stage due to the lack of obvious clinical symptoms in the early stages of GC, and their prognosis is still very poor. The m7G modification is one of the most common forms of base modification in post-transcriptional regulation, and it is widely distributed in the 5' cap region of tRNA, rRNA, and eukaryotic mRNA.

Methods

RNA sequencing data of GC were downloaded from The Cancer Genome Atlas. The differentially expressed m7G-related genes in normal and

SUBMITTER: Li XY 

PROVIDER: S-EPMC9281447 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature