Comprehensive Pan-Cancer Analysis of TRPM8 in Tumor Metabolism and Immune Escape.

ABSTRACT:

Background

Transient receptor potential melastatin 8 (TRPM8) modulates tumor biology and sensitivity to treatment. The present study aimed to determine the part it plays in tumor immunity and physiology using pan-cancer analysis.

Method

Data from the GTEx, CCLE, TISIDB, GSCA, cBioportal, and TCGA databases were collected using Estimate, Scanneo, and GSEA, and the associations between TRPM8 and prognosis, molecular subtypes, mutational burden, microsatellite instability, immune gene functions, and drug sensitivity were analyzed in 33 tumor types.

Result

TRPM8 levels were found to be elevated in most tumors, particularly in solid tumors, with variations according to clinical stage. Mutation frequency was greatest in endometrial carcinoma. High levels of TRPM8 were linke

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9281503 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature