Diagnostic and Predictive Values of Ferroptosis-Related Genes in Child Sepsis.

ABSTRACT:

Background

Early diagnosis of sepsis in children was essential to reducing mortality. This study aimed to explore the value of ferroptosis-related genes in children with sepsis.

Methods

We screened the septic children microarray dataset from the GEO database and analyzed the ferroptosis-related differentially expressed genes (DEGs). A functional analysis of ferroptosis-related DEGs was performed. The protein-protein interaction network was used to identify hub genes. We explored the immune landscape of sepsis and controls. The value of hub genes in diagnosing sepsis was tested in the training (GSE26440) and validation sets (GSE13904), and ELISA was used to verify their diagnostic value in children with sepsis in our hospital.

Results

A total of 2,103 DEGs in GSE26440

SUBMITTER: Li Z 

PROVIDER: S-EPMC9281550 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature