High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction.

ABSTRACT: Gut microbial diurnal oscillations are important diet-dependent drivers of host circadian rhythms and metabolism ensuring optimal energy balance. However, the interplay between diet, microbes, and host factors sustaining intestinal oscillations is complex and poorly understood. Here, using a mouse model, we report the host C-type lectin antimicrobial peptide Reg3γ works with key ileal microbes to orchestrate these interactions in a bidirectional manner and does not correlate with the intestinal core circadian clock. High-fat diet is the primary driver of microbial oscillators that impair host metabolic homeostasis, resulting in arrhythmic host Reg3γ expression that secondarily drives abundance and oscillation of key gut microbes. This illustrates transkingdom coordination of biological rhy

SUBMITTER: Frazier K 

PROVIDER: S-EPMC9281554 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature