Protein Quality Control at the Sarcomere: Titin Protection and Turnover and Implications for Disease Development.

ABSTRACT: Sarcomeres are mainly composed of filament and signaling proteins and are the smallest molecular units of muscle contraction and relaxation. The sarcomere protein titin serves as a molecular spring whose stiffness mediates myofilament extensibility in skeletal and cardiac muscle. Due to the enormous size of titin and its tight integration into the sarcomere, the incorporation and degradation of the titin filament is a highly complex task. The details of the molecular processes involved in titin turnover are not fully understood, but the involvement of different intracellular degradation mechanisms has recently been described. This review summarizes the current state of research with particular emphasis on the relationship between titin and protein quality control. We highlight the involvem

SUBMITTER: Kotter S 

PROVIDER: S-EPMC9281568 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature