Induction of Autophagy Promotes Clearance of RHO^P23H Aggregates and Protects From Retinal Degeneration.

ABSTRACT: Autophagy is a critical metabolic process that acts as a major self-digestion and recycling pathway contributing to maintain cellular homeostasis. An emerging field of research supports the therapeutic modulation of autophagy for treating human neurodegenerative disorders, in which toxic aggregates are accumulated in neurons. Our previous study identified Ezrin protein as an inhibitor of autophagy and lysosomal functions in the retina; thus, in turn, identifying it as a potential pharmacological target for increasing retinal cell clearance to treat inherited retinal dystrophies in which misfolded proteins have accumulated. This study aimed to verify the therapeutic inhibition of Ezrin to induce clearance of toxic aggregates in a mouse model for a dominant form of retinitis pigmentosa (i.e.

SUBMITTER: Intartaglia D 

PROVIDER: S-EPMC9281868 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature