Spatial transcriptomic reconstruction of the mouse olfactory glomerular map suggests principles of odor processing.

ABSTRACT: The olfactory system's ability to detect and discriminate between the vast array of chemicals present in the environment is critical for an animal's survival. In mammals, the first step of this odor processing is executed by olfactory sensory neurons, which project their axons to a stereotyped location in the olfactory bulb (OB) to form glomeruli. The stereotyped positioning of glomeruli in the OB suggests an importance for this organization in odor perception. However, because the location of only a limited subset of glomeruli has been determined, it has been challenging to determine the relationship between glomerular location and odor discrimination. Using a combination of single-cell RNA sequencing, spatial transcriptomics and machine learning, we have generated a map of most glomerula

SUBMITTER: Wang IH 

PROVIDER: S-EPMC9281876 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature