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Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage.

ABSTRACT: Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (Crassostrea gigas) with economic value. OBC is a by-product of boiling oysters at 95°C for 3 min. In this study, we investigated the effects of OBC and its major component taurine on blood and liver tissues obtained from a single-EtOH-binge-drinking mouse model. The preadministration of OBC enhanced EtOH metabolism by increasing the activities of alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and catalase. In addition, the preadministration of OBC reduced cytochrome P450 2E1 (CYP2E1) activity, reactive oxygen species (ROS) generation, Ca²⁺ concentrations, apoptotic signals, and inflammatory mediators in liver tissues. The reduction of apoptotic and inflammatory signals by OBC resulted from the downregulation of endoplasmic reticulum (ER) stress molecules and NF-κB activity. Taurine administration showed similar effects to OBC. These results show that OBC protected against acute EtOH-induced liver damage through the action of taurine. Our findings suggest that OBC could be an economically valuable substance and a functional food with hepatoprotective effects.

SUBMITTER: Siregar AS

PROVIDER: S-EPMC9281932 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage.

Siregar Adrian S AS Nyiramana Marie Merci MM Kim Eun-Jin EJ Shin Eui-Jung EJ Woo Min Seok MS Kim Jin-Mok JM Park Si-Hyang SH Hahm Jong Ryeal JR Choi Yeung Joon YJ Kang Dawon D

Food science & nutrition 20220329 7

Our previous study showed that oyster hydrolysate (OH) protected against the liver damage caused by a single instance of ethanol (EtOH) binge drinking. Oyster broth concentrate (OBC) was discovered in the process of searching for a different substance derived from oysters (<i>Crassostrea gigas</i>) with economic value. OBC is a by-product of boiling oysters at 95°C for 3 min. In this study, we investigated the effects of OBC and its major component taurine on blood and liver tissues obtained fro ...[more]

PMID: 35844927

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Dataset Information

Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage.

Publications

Oyster broth concentrate and its major component taurine alleviate acute alcohol-induced liver damage.

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