Hemophagocytic lymphohistiocytosis in COVID-19: Case reports of a stepwise approach.

ABSTRACT:

Rationale

The immunologic syndrome induced by severe acute coronavirus disease 2019 (COVID-19) is yet not fully understood. Typical patterns of clinical and laboratory features match secondary hemophagocytic lymphohistiocytosis (sHLH). However, the optimal approach to COVID-19 patients testing positive for sHLH is still unclear.

Patient concerns

Three patients with COVID-19 are reviewed. All showed hyperinflammation and cytokine storm, necessitating intensive care treatment including mechanical ventilation.

Diagnosis

Secondary hemophagocytic lymphohistiocytosis due to severe COVID-19; diagnosed via HScore.

Interventions

A treatment regimen of methylprednisolone, pentaglobin, and anakinra was developed and administered.

Outcomes

One patient survived the I

SUBMITTER: Schnaubelt S 

PROVIDER: S-EPMC9281988 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature