PLK1 depletion alters homologous recombination and synaptonemal complex disassembly events during mammalian spermatogenesis.

ABSTRACT: Homologous recombination (HR) is an essential meiotic process that contributes to the genetic variation of offspring and ensures accurate chromosome segregation. Recombination is facilitated by the formation and repair of programmed DNA double-strand breaks. These DNA breaks are repaired via recombination between maternal and paternal homologous chromosomes and a subset result in the formation of crossovers. HR and crossover formation is facilitated by synapsis of homologous chromosomes by a proteinaceous scaffold structure known as the synaptonemal complex (SC). Recent studies in yeast and worms have indicated that polo-like kinases (PLKs) regulate several events during meiosis, including DNA recombination and SC dynamics. Mammals express four active PLKs (PLK1-4), and our previous work a

SUBMITTER: Wellard SR 

PROVIDER: S-EPMC9282006 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature