Viral shedding in gastroenteritis in children caused by variants and novel recombinant norovirus infections.

ABSTRACT:

Abstract

Human norovirus (NoV) is the leading cause of acute gastroenteritis and the rapid transmission of NoV renders infection control problematic. Our study aimed to investigate viral shedding in gastroenteritis in children caused by variants of emerging norovirus strains infections.We used RNA-dependent RNA polymerase (RdRp) sequencing to measure NoV genome copies in stool to understand the relationship between the clinical manifestations and viral shedding in hospitalized patients. The near full-length NoV genome sequence was amplified via reverse transcription-polymerase chain reaction (RT-PCR) and NoV recombination was analyzed using the Recombination Analysis Tool (RAT).From January 2015 to March 2018, 77 fecal specimens were collected from hospitalized pediatric patients w

SUBMITTER: Cheng HY 

PROVIDER: S-EPMC9282056 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature