Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway.

ABSTRACT: Crocin is a monomer of Chinese traditional herbs extracted from saffron, relieving depression-like behavior. However, its underlying mechanism of action remains unclear. Herein, we explored whether crocin's antidepressant effect depended on the mammalian target of the rapamycin (mTOR) signaling pathway. The model of PC12 cells injury was established by corticosterone, the changes in cell survival rate were tested by the CCK-8 method, and the changes in cellular morphology were observed under a fluorescence microscope. The depression model was established by chronic unpredictable mild stress (CUMS), and its antidepressant effect was estimated by open field test (OFT), forced swimming test (FST), and tail suspension test (TST). Western blot was used to monitor the protein expression. The res

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9282155 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature