Metabolomic Identification of a Novel, Externally Validated Predictive Test for Gestational Diabetes Mellitus.

ABSTRACT:

Context

Undiagnosed gestational diabetes mellitus (GDM) is a major preventable cause of stillbirth. In the United Kingdom, women are selected for diagnostic testing for GDM based on risk factors, including body mass index (BMI) > 30 kg/m2.

Objective

To improve the prediction of GDM using metabolomics.

Methods

We performed metabolomics on maternal serum from the Pregnancy Outcome Prediction (POP) study at 12 and 20 weeks of gestational age (wkGA; 185 GDM cases and 314 noncases). Predictive metabolites were internally validated using the 28 wkGA POP study serum sample and externally validated using 24- to 28-wkGA fasting plasma from the Born in Bradford (BiB) cohort (349 GDM cases and 2347 noncases). The predictive ability of a model including the metabolites was compar

SUBMITTER: Sovio U 

PROVIDER: S-EPMC9282248 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature