Genome-wide DNA Methylation Differences in Nonfunctioning Pituitary Adenomas With and Without Postsurgical Progression.

ABSTRACT:

Context

Tumor progression in surgically treated patients with nonfunctioning pituitary adenomas (NFPAs) is associated with excess mortality. Reliable biomarkers allowing early identification of tumor progression are missing.

Objective

To explore DNA methylation patterns associated with tumor progression in NFPA patients.

Methods

This case-controlled exploratory trial at a university hospital studied patients who underwent surgery for NFPA that had immunohistochemical characteristics of a gonadotropinoma. Cases included patients requiring reintervention due to tumor progression (reintervention group, n = 26) and controls who had a postoperative residual tumor without tumor progression for at least 5 years (radiologically stable group, n = 17). Genome-wide methylation d

SUBMITTER: Hallen T 

PROVIDER: S-EPMC9282265 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature