Reproducibility of Densitometric and Biomechanical Assessment of the Mouse Tibia From <i>In Vivo</i> Micro-CT Images.

ABSTRACT: Interventions for bone diseases (e.g. osteoporosis) require testing in animal models before clinical translation and the mouse tibia is among the most common tested anatomical sites. In vivo micro-Computed Tomography (microCT) based measurements of the geometrical and densitometric properties are non-invasive and therefore constitute an important tool in preclinical studies. Moreover, validated micro-Finite Element (microFE) models can be used for predicting the bone mechanical properties non-invasively. However, considering that the image processing pipeline requires operator-dependant steps, the reproducibility of these measurements has to be assessed. The aim of this study was to evaluate the intra- and inter-operator reproducibility of several bone parameters measured from micro

SUBMITTER: Oliviero S 

PROVIDER: S-EPMC9282377 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature