Transforming growth factor-β signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta.

ABSTRACT: Abnormal placentation has been noticed in a variety of pregnancy complications such as miscarriage, early-onset preeclampsia, and fetal growth restriction. Defects in the developmental program of extravillous trophoblasts (EVTs), migrating from placental anchoring villi into the maternal decidua and its vessels, is thought to be an underlying cause. Yet, key regulatory mechanisms controlling commitment and differentiation of the invasive trophoblast lineage remain largely elusive. Herein, comparative gene expression analyses of HLA-G-purified EVTs, isolated from donor-matched placenta, decidua, and trophoblast organoids (TB-ORGs), revealed biological processes and signaling pathways governing EVT development. In particular, bioinformatics analyses and manipulations in different versatile t

SUBMITTER: Haider S 

PROVIDER: S-EPMC9282384 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature