Ontology highlight
ABSTRACT:
SUBMITTER: Duru N
PROVIDER: S-EPMC9282395 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Duru Nadire N Pawar Nisha R NR Martin Erik W EW Buzza Marguerite S MS Conway Gregory D GD Lapidus Rena G RG Liu Shihui S Reader Jocelyn J Rao Gautam G GG Roque Dana M DM Leppla Stephen H SH Antalis Toni M TM
Proceedings of the National Academy of Sciences of the United States of America 20220708 28
Treatments for advanced and recurrent ovarian cancer remain a challenge due to a lack of potent, selective, and effective therapeutics. Here, we developed the basis for a transformative anticancer strategy based on anthrax toxin that has been engineered to be selectively activated by the catalytic power of zymogen-activating proteases on the surface of malignant tumor cells to induce cell death. Exposure to the engineered toxin is cytotoxic to ovarian tumor cell lines and ovarian tumor spheroids ...[more]