Polygenic and socioeconomic risk for high body mass index: 69 years of follow-up across life.

ABSTRACT: Genetic influences on body mass index (BMI) appear to markedly differ across life, yet existing research is equivocal and limited by a paucity of life course data. We thus used a birth cohort study to investigate differences in association and explained variance in polygenic risk for high BMI across infancy to old age (2-69 years). A secondary aim was to investigate how the association between BMI and a key purported environmental determinant (childhood socioeconomic position) differed across life, and whether this operated independently and/or multiplicatively of genetic influences. Data were from up to 2677 participants in the MRC National Survey of Health and Development, with measured BMI at 12 timepoints from 2-69 years. We used multiple polygenic indices from GWAS of adult and childh

SUBMITTER: Bann D 

PROVIDER: S-EPMC9282556 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature