Neuroprotective effects of Canagliflozin: Lessons from aged genetically diverse UM-HET3 mice.

ABSTRACT: The aging brain is characterized by progressive increases in neuroinflammation and central insulin resistance, which contribute to neurodegenerative diseases and cognitive impairment. Recently, the Interventions Testing Program demonstrated that the anti-diabetes drug, Canagliflozin (Cana), a sodium-glucose transporter 2 inhibitor, led to lower fasting glucose and improved glucose tolerance in both sexes, but extended median lifespan by 14% in male mice only. Here, we show that Cana treatment significantly improved central insulin sensitivity in the hypothalamus and the hippocampus of 30-month-old male mice. Aged males produce more robust neuroimmune responses than aged females. Remarkably, Cana-treated male and female mice showed significant reductions in age-associated hypothalamic glios

SUBMITTER: Jayarathne HSM 

PROVIDER: S-EPMC9282842 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature