Exercise increases the release of NAMPT in extracellular vesicles and alters NAD⁺ activity in recipient cells.

ABSTRACT: Aging is associated with a loss of metabolic homeostasis, with cofactors such as nicotinamide adenine dinucleotide (NAD⁺ ) declining over time. The decrease in NAD⁺ production has been linked to the age-related loss of circulating extracellular nicotinamide phosphoribosyltransferase (eNAMPT), the rate-limiting enzyme in the NAD⁺ biosynthetic pathway. eNAMPT is found almost exclusively in extracellular vesicles (EVs), providing a mechanism for the distribution of the enzyme in different tissues. Currently, the physiological cause for the release of eNAMPT is unknown, and how it may be affected by age and physical exercise. Here, we show that release of small EVs into the bloodstream is stimulated following moderate intensity exercise in humans. Exercise also

SUBMITTER: Chong MC 

PROVIDER: S-EPMC9282849 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature