Creatine riboside is a cancer cell-derived metabolite associated with arginine auxotrophy.

ABSTRACT: The metabolic dependencies of cancer cells have substantial potential to be exploited to improve the diagnosis and treatment of cancer. Creatine riboside (CR) is identified as a urinary metabolite associated with risk and prognosis in lung and liver cancer. However, the source of high CR levels in patients with cancer as well as their implications for the treatment of these aggressive cancers remain unclear. By integrating multiomics data on lung and liver cancer, we have shown that CR is a cancer cell-derived metabolite. Global metabolomics and gene expression analysis of human tumors and matched liquid biopsies, together with functional studies, revealed that dysregulation of the mitochondrial urea cycle and a nucleotide imbalance were associated with high CR levels and indicators of a p

SUBMITTER: Parker AL 

PROVIDER: S-EPMC9282934 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature