Diffusion tractography predicts propagated high-frequency activity during epileptic spasms.

ABSTRACT:

Objective

To determine the structural networks that constrain propagation of ictal oscillations during epileptic spasm events, and compare the observed propagation patterns across patients with successful or unsuccessful surgical outcomes.

Methods

Subdural electrode recordings of 18 young patients (age 1-11 years) were analyzed during epileptic spasm events to determine ictal networks and quantify the amplitude and onset time of ictal oscillations across the cortical surface. Corresponding structural networks were generated with diffusion magnetic resonance imaging (MRI) tractography by seeding the cortical region associated with the earliest average oscillation onset time, and white matter pathways connecting active electrode regions within the ictal network were isolated.

SUBMITTER: O'Hara NB 

PROVIDER: S-EPMC9283246 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature