Body composition is associated with tacrolimus pharmacokinetics in kidney transplant recipients.

ABSTRACT:

Purpose

A population pharmacokinetic (popPK) model may be used to improve tacrolimus dosing and minimize under- and overexposure in kidney transplant recipients. It is unknown how body composition parameters relate to tacrolimus pharmacokinetics and which parameter correlates best with tacrolimus exposure. The aims of this study were to investigate which body composition parameter has the best association with the pharmacokinetics of tacrolimus and to describe this relationship in a popPK model.

Methods

Body composition was assessed using bio-impedance spectroscopy (BIS). Pharmacokinetic analysis was performed using nonlinear mixed effects modeling (NONMEM). Lean tissue mass, adipose tissue mass, over-hydration, and phase angle were measured with BIS and then evaluated as co

SUBMITTER: Francke MI 

PROVIDER: S-EPMC9283366 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature