Nucleus accumbens D1-receptors regulate and focus transitions to reward-seeking action.

ABSTRACT: It is well established that dopamine transmission is integral in mediating the influence of reward expectations on reward-seeking actions. However, the precise causal role of dopamine transmission in moment-to-moment reward-motivated behavioral control remains contentious, particularly in contexts where it is necessary to refrain from responding to achieve a beneficial outcome. To examine this, we manipulated dopamine transmission pharmacologically as rats performed a Go/No-Go task that required them to either make or withhold action to gain either a small or large reward. D1R Stimulation potentiated cue-driven action initiation, including fast impulsive actions on No-Go trials. By contrast, D1R blockade primarily disrupted the successful completion of Go trial sequences. Surprisingly, whi

SUBMITTER: Grima LL 

PROVIDER: S-EPMC9283443 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature