Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application.

ABSTRACT: Electromagnetic radiation-triggered therapeutic effect has attracted a great interest over the last 50 years. However, translation to clinical applications of photoactive molecular systems developed to date is dramatically limited, mainly because their activation requires excitation by low-energy photons from the ultraviolet to near infra-red range, preventing any activation deeper than few millimetres under the skin. Herein we conceive a strategy for photosensitive-system activation potentially adapted to biological tissues without any restriction in depth. High-energy stimuli, such as those employed for radiotherapy, are used to carry energy while molecular activation is provided by local energy conversion. This concept is applied to azobenzene, one of the most established photoswitches,

SUBMITTER: Guesdon-Vennerie A 

PROVIDER: S-EPMC9283480 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature