A non-invasive multipoint product temperature measurement for pharmaceutical lyophilization.

ABSTRACT: Monitoring product temperature during lyophilization is critical, especially during the process development stage, as the final product may be jeopardized if its process temperature exceeds a threshold value. Also, in-situ temperature monitoring of the product gives the capability of creating an optimized closed-loop lyophilization process. While conventional thermocouples can track product temperature, they are invasive, limited to a single-point measurement, and can significantly alter the freezing and drying behavior of the product in the monitored vial. This work has developed a new methodology that combines non-invasive temperature monitoring and comprehensive modeling. It allows the accurate reconstruction of the complete temperature profile of the product inside the vial during the

SUBMITTER: Jiang X 

PROVIDER: S-EPMC9283482 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature