Intermittent calorie restriction alters T cell subsets and metabolic markers in people with multiple sclerosis.

ABSTRACT:

Background

Intermittent fasting or calorie restriction (CR) diets provide anti-inflammatory and neuroprotective advantages in models of multiple sclerosis (MS); data in humans are sparse.

Methods

We conducted a randomised-controlled feeding study of different CR diets in 36 people with MS over 8 weeks. Participants were randomised to 1 of 3 diets: 1) a control diet, in which the participant received 100% of his or her calorie needs 7 days per week, 2) a daily CR diet, in which the participant received 78% of his or her calorie needs 7 days per week, or 3) an intermittent CR diet, in which the participant received 100% of his or her calorie needs on 5 days per week and 25% of his or her calorie needs 2 days per week (i.e., a "5:2" style diet). Untargeted metabolomics was perf

SUBMITTER: Fitzgerald KC 

PROVIDER: S-EPMC9283513 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature