Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.

ABSTRACT: Hypertension and kidney disease have been repeatedly associated with genomic variants and alterations of lysine metabolism. Here, we combined stable isotope labeling with untargeted metabolomics to investigate lysine's metabolic fate in vivo. Dietary ¹³C₆ labeled lysine was tracked to lysine metabolites across various organs. Globally, lysine reacts rapidly with molecules of the central carbon metabolism, but incorporates slowly into proteins and acylcarnitines. Lysine metabolism is accelerated in a rat model of hypertension and kidney damage, chiefly through N-alpha-mediated degradation. Lysine administration diminished development of hypertension and kidney injury. Protective mechanisms include diuresis, further acceleration of lysine conjugate formation, and inhibi

SUBMITTER: Rinschen MM 

PROVIDER: S-EPMC9283537 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature