TIGIT Deficiency Protects Mice From DSS-Induced Colitis by Regulating IL-17A-Producing CD4⁺ Tissue-Resident Memory T Cells.

ABSTRACT: Tissue-resident memory T cells (T_RM cells) have been shown to play an instrumental role in providing local immune responses for pathogen clearance in barrier tissues. However, their contribution to inflammatory bowel diseases (IBDs) and the underlying regulation are less clear. Here, we identified a critical role of T-cell immunoreceptor with immunoglobulin and ITIM (TIGIT) in regulating CD4⁺ T_RM cells in an experimental model of intestinal inflammation. We found that CD4+ TRM cells were increased and correlated with disease activities in mice with dextran sulfate sodium (DSS)-induced colitis. Phenotypically, these CD4⁺ T_RM cells could be classified into CD69⁺CD103^- and CD69⁺CD103⁺ subsets. F

SUBMITTER: Chen B 

PROVIDER: S-EPMC9283574 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature