Medical and Non-medical Costs of Sickle Cell Disease and Treatments from a US Perspective: A Systematic Review and Landscape Analysis.

ABSTRACT:

Background

Sickle cell disease (SCD) is a complex genetic disorder that manifests in infancy and progresses throughout life in the form of acute and chronic complications. As the upfront costs of potentially curative, genetic therapies will likely be high, an assessment and comprehensive characterization of the medical and non-medical cost burden will inform future decision making.

Objective

We sought to systematically summarize the existing literature surrounding SCD medical and non-medical costs.

Methods

We searched MEDLINE and EMBASE (2008-2020) and identified US-based studies that detailed medical or non-medical costs. Eligible studies provided empirical estimates about any aspect of cost or SCD individuals of all ages and their caregivers. Study quality was asses

SUBMITTER: Baldwin Z 

PROVIDER: S-EPMC9283624 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature