Discovery of preventive drugs for cisplatin-induced acute kidney injury using big data analysis.

ABSTRACT: Cisplatin is effective against many types of carcinoma. However, a high rate of renal damage is a clinical problem. Thus, there is a need to establish a method to prevent it. Although various compounds have been reported to be effective against cisplatin-induced renal injury, there are no examples of their clinical application. Therefore, we attempted to search for prophylactic agents with a high potential for clinical application. We used Cascade Eye to identify genes that are altered during cisplatin-induced renal injury, Library of Integrated Network-based Cellular Signatures (LINCS) to identify drugs that inhibit changes in gene expression, and a large database of spontaneous adverse drug reaction reports to identify drugs that could prevent cisplatin-induced kidney injury in clinical

SUBMITTER: Kanda M 

PROVIDER: S-EPMC9283743 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature