IL-6 gene rs1800795 polymorphism and diabetes mellitus: a comprehensive analysis involving 42,150 participants from a meta-analysis.

ABSTRACT:

Background

Over the past two decades, several studies have focused on the association between a common polymorphism (rs1800795) from interleukin-6 (IL-6) gene and Diabetes Mellitus (DM) risk. However, the results remain ambiguous and indefinite.

Methods

A comprehensive analysis was performed to explore this relationship. A search was conducted in the PubMed, Embase, Chinese (CNKI and Wanfang), and GWAS Catalog databases, covering all publications until February 10, 2022. Odds ratios (OR) with 95% confidence intervals (CI) were used to evaluate the strength of the association. Publication bias was assessed using both Begg and Egger tests.

Results

Overall, 34 case-control studies with 7257 T2DM patients and 15,598 controls, and 12 case-control studies (10,264 T1DM patie

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC9283852 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature