Expression Profile of Immunoglobulin G Glycosylation in Children With Epilepsy in Han Nationality.

ABSTRACT:

Background

Epilepsy is a chronic brain disease that recurs during childhood, and more than half of adult epilepsy originates from childhood. Studies suggested that immunoglobulin G (IgG) glycosylation are closely related to neurological diseases. Here we analyzed the characteristics of the immunoglobulin glycosylation profile of children with epilepsy.

Methods

Patients were recruited in Taian, Shandong Province from December 2019 to March 2020. Serum IgG glycome composition was analyzed by hydrophilic interaction liquid chromatography with ultra-high-performance liquid chromatography approach.

Results

The proportion of fucosylated glycans in total IgG glycans was 93.72% in the epilepsy patients, which was significantly lower than that in the control group (94.94%). A

SUBMITTER: Li Y 

PROVIDER: S-EPMC9283856 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature