Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy.

ABSTRACT: Pregnancy requires adaptations in maternal metabolism to support fetal growth. The phosphoinositol-3-kinase (PI3K) signalling pathway controls multiple biological processes and defects in this pathway are linked to metabolic disorders including insulin resistance and glucose intolerance in non-pregnant animals. However, relatively little is known about the contribution of PI3K signalling to the maternal metabolic adaptations during pregnancy. Using mice with partial inactivation of the PI3K isoform, p110α (due to a heterozygous dominant negative mutation; Pik3ca-D933A), the effects of impaired PI3K-p110α signalling on glucose and insulin handling were examined in the pregnant and non-pregnant states and related to the morphological, molecular, and mitochondrial changes in key metabo

SUBMITTER: Lopez-Tello J 

PROVIDER: S-EPMC9283861 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature