Commonalities of <i>Mycobacterium tuberculosis</i> Transcriptomes in Response to Defined Persisting Macrophage Stresses.

ABSTRACT: As the goal of a bacterium is to become bacteria, evolution has imposed continued selections for gene expression. The intracellular pathogen Mycobacterium tuberculosis, the causative agent of tuberculosis, has adopted a fine-tuned response to survive its host's methods to aggressively eradicate invaders. The development of microarrays and later RNA sequencing has led to a better understanding of biological processes controlling the relationship between host and pathogens. In this study, RNA-seq was performed to detail the transcriptomes of M. tuberculosis grown in various conditions related to stresses endured by M. tuberculosis during host infection and to delineate a general stress response incurring during persisting macrophage stresses. M. tuberculosis was s

SUBMITTER: Vilcheze C 

PROVIDER: S-EPMC9283954 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature