Metabolic Syndrome Predicts Response to Neoadjuvant Chemotherapy in Breast Cancer.

ABSTRACT:

Purpose

This research investigated the predictive role of metabolic syndrome (MetS) in breast cancer neoadjuvant chemotherapy (BCNACT) response.

Methods

One hundred fifty primary breast cancer (BC) patients who underwent neoadjuvant chemotherapy (NACT) were included retrospectively. MetS, MetS components [waist circumference (WC), fasting blood glucose (FBG), blood pressure, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)], serum lipid, and other MetS-related laboratory indicators within two weeks before BCNACT were evaluated. Univariate, multivariate, and subgroup analyses were performed to determine the predictors of BCNACT pathologic complete response (pCR), clinical response, and pathologic response. The effectiveness of the model was evaluated vi

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9284232 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature