Association of Intratumoral Microbiota With Prognosis in Patients With Nasopharyngeal Carcinoma From 2 Hospitals in China.

ABSTRACT:

Importance

Microbiota-tumor interactions have qualified microbiota as a promising prognostic biomarker in various types of cancers. Although the nasopharynx acts as a crucial niche of the upper respiratory tract microbiome, whether the intratumoral microbiota exists and its clinical significance in nasopharyngeal carcinoma (NPC) remain uncertain.

Objective

To evaluate the clinical significance of intratumoral microbiota for individual prognostication in patients with NPC.

Design, setting, and participants

This retrospective cohort study included NPC biopsy samples from 2 hospitals: Sun Yat-sen University Cancer Center (Guangzhou, China) and Zhejiang Cancer Hospital (Hangzhou, China) between January 2004 and November 2016, with follow-up through November 2020. A total

SUBMITTER: Qiao H 

PROVIDER: S-EPMC9284409 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature