Identification of Potential Antigens for Developing mRNA Vaccine for Immunologically Cold Mesothelioma.

ABSTRACT: Messenger RNA vaccines are considered to be a promising strategy in cancer immunotherapy, while their application on mesothelioma is still largely uncharacterized. This study aimed to identify potential antigens in mesothelioma for anti-mesothelioma mRNA vaccine development, and further determine the immune subtypes of mesothelioma for selection of suitable candidates from an extremely heterogeneous population. Gene expression data and corresponding clinicopathological information were obtained from the TCGA and gene expression omnibus, respectively. Then, the genetic alterations were compared and visualized using cBioPortal, and differentially expressed genes and their prognostic signatures were identified by GEPIA. The relationship between tumor-infiltrating immune cells and the expressi

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9284534 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature