DNA Strand-Displacement Temporal Logic Circuits.

ABSTRACT: Molecular circuits capable of processing temporal information are essential for complex decision making in response to both the presence and history of a molecular environment. A particular type of temporal information that has been recognized to be important is the relative timing of signals. Here we demonstrate the strategy of temporal memory combined with logic computation in DNA strand-displacement circuits capable of making decisions based on specific combinations of inputs as well as their relative timing. The circuit encodes the timing information on inputs in a set of memory strands, which allows for the construction of logic gates that act on current and historical signals. We show that mismatches can be employed to reduce the complexity of circuit design and that shortening speci

SUBMITTER: Lapteva AP 

PROVIDER: S-EPMC9284558 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature