Ontology highlight
ABSTRACT:
SUBMITTER: Shi W
PROVIDER: S-EPMC9284671 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Shi Wei W Wang Lingshu L Zhou Tongqing T Sastry Mallika M Yang Eun Sung ES Zhang Yi Y Chen Man M Chen Xuejun X Choe Misook M Creanga Adrian A Leung Kwan K Olia Adam S AS Pegu Amarendra A Rawi Reda R Schön Arne A Shen Chen-Hsiang CH Stancofski Erik-Stephane D ED Talana Chloe Adrienna CA Teng I-Ting IT Wang Shuishu S Corbett Kizzmekia S KS Tsybovsky Yaroslav Y Mascola John R JR Kwong Peter D PD
Structure (London, England : 1993) 20220715 9
Immunization with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike elicits diverse antibodies, but it is unclear if any of the antibodies can neutralize broadly against other beta-coronaviruses. Here, we report antibody WS6 from a mouse immunized with mRNA encoding the SARS-CoV-2 spike. WS6 bound diverse beta-coronavirus spikes and neutralized SARS-CoV-2 variants, SARS-CoV, and related sarbecoviruses. Epitope mapping revealed WS6 to target a region in the S2 subunit, which was ...[more]