Titanium dioxide and carbon black nanoparticles disrupt neuronal homeostasis via excessive activation of cellular prion protein signaling.

ABSTRACT:

Background

Epidemiological emerging evidence shows that human exposure to some nanosized materials present in the environment would contribute to the onset and/or progression of Alzheimer's disease (AD). The cellular and molecular mechanisms whereby nanoparticles would exert some adverse effects towards neurons and take part in AD pathology are nevertheless unknown.

Results

Here, we provide the prime evidence that titanium dioxide (TiO₂) and carbon black (CB) nanoparticles (NPs) bind the cellular form of the prion protein (PrP^C), a plasma membrane protein well known for its implication in prion diseases and prion-like diseases, such as AD. The interaction between TiO₂- or CB-NPs and PrP^C at the surface of neuronal cells grown in cu

SUBMITTER: Ribeiro LW 

PROVIDER: S-EPMC9284759 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature