The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.

ABSTRACT:

Background

Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk.

Methods

Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, bo

SUBMITTER: Ward SV 

PROVIDER: S-EPMC9284807 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature