Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges.

ABSTRACT: Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune destruction of insulin-producing β-pancreatic cells. Although many advances have been achieved in T1D treatment, current therapy strategies are often unable to maintain perfect control of glycemic levels. Several studies are searching for new and improved methodologies for expansion of β-cell cultures in vitro to increase the supply of these cells for pancreatic islets replacement therapy. A promising approach consists of differentiation of stem cells into insulin-producing cells (IPCs) in sufficient number and functional status to be transplanted. Differentiation protocols have been designed using consecutive cytokines or signaling modulator treatments, at specific dosages, to activate or inhibit the main s

SUBMITTER: Silva IBB 

PROVIDER: S-EPMC9284809 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature