Dataset Information

MicroRNA-145-5p modulates Kruppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma.

ABSTRACT:

Background

In several human cancers, Krüppel-like factor 5 (KLF5), a zinc finger transcription factor, can contribute to both tumor progression or suppression; however, the precise role of KLF5 in nasopharyngeal carcinoma (NPC) remains poorly understood. In this study, the association between KLF5 and microRNA-145-5p (miR-145-5p) in NPC cells was elucidated.

Results

Our results showed that KLF5 expression was up-regulated in NPC group compared to normal group. We found that KLF5 exhibited an oncogenic role in NPC cells. The upregulation of miR-145-5p inhibited the proliferation, migration, and invasion of NPC cells. It was observed that miR-145-5p could down-regulate the mRNA and protein expression of KLF5 in NPC cell lines. Additionally, the activity of focal adhesion kinase (FAK), a migration marker, was regulated by miR-145-5p and KLF5 in NPC cells.

Conclusions

The results of this study indicated that miR-145-5p could repress the proliferation, migration, and invasion of NPC cells via KLF5/FAK regulation, and could be a potential therapeutic target for patients with NPC.

SUBMITTER: Yuan CH

PROVIDER: S-EPMC9284881 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

MicroRNA-145-5p modulates Krüppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma.

Yuan Chien-Han CH Hsu Wei-Chi WC Huang A-Mei AM Yuan Ben-Chih BC Chen I-Hung IH Hsu Chia-An CA Chen Rong-Feng RF Chu Yih-Min YM Lin Hui-Hui HH Ke Hung-Lung HL

BMC molecular and cell biology 20220714 1

<h4>Background</h4>In several human cancers, Krüppel-like factor 5 (KLF5), a zinc finger transcription factor, can contribute to both tumor progression or suppression; however, the precise role of KLF5 in nasopharyngeal carcinoma (NPC) remains poorly understood. In this study, the association between KLF5 and microRNA-145-5p (miR-145-5p) in NPC cells was elucidated.<h4>Results</h4>Our results showed that KLF5 expression was up-regulated in NPC group compared to normal group. We found that KLF5 e ...[more]

PMID: 35836107

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