Nonalcoholic fatty liver disease, circulating ketone bodies and all-cause mortality in a general population-based cohort.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, paralleling the obesity epidemic. Ketone bodies are produced in the liver, but it is currently uncertain whether circulating ketone bodies are increased in the context of NAFLD. We investigated the association between NAFLD and circulating ketone bodies and determined the extent to which NAFLD and circulating ketone bodies are associated with all-cause mortality.

Methods

Plasma ketone bodies were measured by nuclear magnetic resonance spectroscopy in participants of the general population-based PREVEND study. A fatty liver index (FLI) ≥60 was regarded as a proxy of NAFLD. Associations of an elevated FLI and ketone bodies with all-cause mortality were investigated using Cox regression analyses.

SUBMITTER: Post A 

PROVIDER: S-EPMC9285047 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature