Whole-brain high-resolution metabolite mapping with 3D compressed-sensing SENSE low-rank ¹ H FID-MRSI.

ABSTRACT: There is a growing interest in the neuroscience community to map the distribution of brain metabolites in vivo. Magnetic resonance spectroscopic imaging (MRSI) is often limited by either a poor spatial resolution and/or a long acquisition time, which severely restricts its applications for clinical and research purposes. Building on a recently developed technique of acquisition-reconstruction for 2D MRSI, we combined a fast Cartesian ¹ H-FID-MRSI acquisition sequence, compressed-sensing acceleration, and low-rank total-generalized-variation constrained reconstruction to produce 3D high-resolution whole-brain MRSI with a significant acquisition time reduction. We first evaluated the acceleration performance using retrospective undersampling of a fully sampled dataset. Second, a 2

SUBMITTER: Klauser A 

PROVIDER: S-EPMC9285075 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature