A Novel Prognostic Nomogram for Predicting Survival of Hormone Receptor-Positive and HER2 Negative Advanced Breast Cancer Among the Han-Population.

ABSTRACT:

Purpose

To develop a nomogram model to predict overall survival in HR+/HER2- subtype advanced breast cancer.

Methods

A total of 3,577 ABC (advanced breast cancer) patients from 21 hospitals in China were involved in this study from January 2012 to December 2014. From all ABC patients, 1,671 HR+/HER2- ABC patients were extracted and enrolled in our study. A nomogram was built based on univariable and multivariable Cox regression analyses, identifying independent predictors. The discriminatory and predictive capacities of the nomogram were assessed using the ROC (receiver operating characteristic) curve and calibration plots.

Results

Univariable and multivariable analysis found that ER (estrogen receptor) status, MFIs (metastatic-free intervals), first-line therapy opti

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC9285102 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature