Glow flow ionization mass spectrometry of small molecules. A comparison of a glow flow ionization source ('GlowFlow') with electrospray ionization and atmospheric pressure chemical ionization.

ABSTRACT:

Rationale

Ionization by atmospheric pressure gas discharge has been employed for a long time in mass spectrometry. Inductively coupled plasma mass spectrometry is an exemplar, and widely used for elemental analysis. The technique has less uptake in organic mass spectrometry. We describe a simple source design that can be readily implemented in most atmospheric pressure ionization (API) systems and compare its performance with that of electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI).

Methods

An in-house designed helium gas discharge source (referred to as 'GlowFlow') was used on a Xevo G2-S time-of-flight mass spectrometer. The GlowFlow source was transferred to a compatible Xevo TQ-S triple-quadrupole mass spectrometer using an ultrahigh-perf

SUBMITTER: Owen RN 

PROVIDER: S-EPMC9285393 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature