Amoxicillin does not affect the development of cow's milk allergy in a Brown Norway rat model.

ABSTRACT: The use of antibiotics as well as changes in the gut microbiota have been linked to development of food allergy in childhood. It remains unknown whether administration of a single clinically relevant antibiotic directly promotes food allergy development when administrated during the sensitisation phase in an experimental animal model. We investigated whether the antibiotic amoxicillin affected gut microbiota composition, development of cow's milk allergy (CMA) and frequencies of allergic effector cells and regulatory T cells in the intestine. Brown Norway rats were given daily oral gavages of amoxicillin for six weeks and whey protein concentrate (WPC) with or without cholera toxin three times per week for the last five weeks. Microbiota composition in faeces and small intestine was analys

SUBMITTER: Locke AV 

PROVIDER: S-EPMC9285443 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature